Calendar

Add to Calendar 9/18/2019 4:00 pm 9/18/2019 America/Chicago Physics Colloquium: “Randomness and Hidden Variables in the Living Cell” DESCRIPTION:

Our ability to understand, predict, and manipulate the behavior of living systems is severely limited by cellular individuality: Genetically identical cells, within a uniform environment, nevertheless exhibit heterogeneous behavior. Studies over the last two decades have highlighted the stochastic origins of cellular individuality, by demonstrating that the inherent randomness of single-molecule events can be amplified into copy-number fluctuations at the cellular level. The picture that emerged is of living cells as “noisy machines”, whose behavior can only be described probabilistically. However, an important caveat to the stochastic view of cellular individuality is that what appears as noise may, in fact, reflect the presence of deterministic drivers of cell-to-cell differences. Failure to detect these “hidden variables” makes cellular behavior appear more random that it truly is. Conversely, properly accounting for them would reveal the precision at which living cells function.

\n\nSPEAKER: Ido Golding, University of Illinois
141 Loomis false

Physics Colloquium: “Randomness and Hidden Variables in the Living Cell”

Speaker Ido Golding, University of Illinois
Date: 9/18/2019
Time: 4 p.m.
Location: 141 Loomis
Event Contact: Suzanne Hallihan
217-333-3760
shalliha@illinois.edu
Sponsor: University of Illinois Department of Physics
Event Type: Other
 

Our ability to understand, predict, and manipulate the behavior of living systems is severely limited by cellular individuality: Genetically identical cells, within a uniform environment, nevertheless exhibit heterogeneous behavior. Studies over the last two decades have highlighted the stochastic origins of cellular individuality, by demonstrating that the inherent randomness of single-molecule events can be amplified into copy-number fluctuations at the cellular level. The picture that emerged is of living cells as “noisy machines”, whose behavior can only be described probabilistically. However, an important caveat to the stochastic view of cellular individuality is that what appears as noise may, in fact, reflect the presence of deterministic drivers of cell-to-cell differences. Failure to detect these “hidden variables” makes cellular behavior appear more random that it truly is. Conversely, properly accounting for them would reveal the precision at which living cells function.

To request disability-related accommodations for this event, please contact the person listed above, or the unit hosting the event.

Event Mailing List

Receive Illinois Physics events weekly in your inbox.

Sign-up!


Remove me!