Graduate Research Position in Prof. Diwakar Shukla's Group

Graduate student position in Shukla Group

The Shukla Group in Chemical and Biomolecular Engineering has an opening for a graduate student.  The graduate student positions in Shukla Group involve research in high performance computing and biomolecular modeling of plant and human proteins. The projects are focused on investigating cellular signaling mechanisms of Kinases and GPCRs, which are implicated in a variety of human diseases and stress (such as drought, salinity, pests etc.) related signaling in plants. During the course of the project, students would learn novel simulations methodologies such as cloud and distributed computing, Markov state model analysis of the simulations of complex biological systems etc. The scope of the project is not limited to application of molecular simulations but could also involve development of novel computational algorithms and methods related to parallel programming, multi scale modeling and data analysis. For more details, please visit our website at http://www.shuklagroup.org or email Diwakar at diwakar.shukla@shuklagroup.org.

Broad details of the methods and project could be found in our recent publications included below.

D. Shukla, A. Peck and V. S. Pande, Conformational Heterogeneity of Calmodulin’s Binding Interface, Nature Communications, 2015.

J. Weber, D. Shukla and V. S. Pande, Heat Dissipation Guides Activation in Signaling Proteins, Proceedings of National Academy of Sciences (PNAS), 2015.

D. Shukla, Y. Meng, B. Roux and V. S. Pande, Activation Pathway of Src Kinase Reveals Intermediate States as Novel Targets for Drug Design. Nature Communications, 5:3397, doi: 10.1038/ncomms4397, 2014.

K. Kohlhoff*, D. Shukla*, M. Lawrenz* , G. R. Bowman, D. E. Konerding, D. Belov, R. B. Altman and V. S. Pande, Cloud-based simulations on Google Exacycle reveal ligand-modulation of GPCR activation pathways., Nature Chemistry, Vol. 6, 15–21, 2014.