In a paper in Nano Letters ("Optical Voltage Sensing Using DNA Origami"), a research team, led by Keyser, Philip Tinnefeld from the Institute of Physical and Theoretical Chemistry at Technical University Braunschweig, and Aleksei Aksimentiev from the University of Illinois at Urbana-Champaign, has now reported for the first time, that a voltage can be read out in a nanopore with a dedicated Förster resonance energy transfer (FRET) sensor on a DNA origami.
What is Biological Physics?
In 1944, physicist Erwin Schrödinger published a short book, What is Life?, that changed the course of modern biology.
Could the behavior of a living organism be explained solely by physics and chemistry? Yes, it could, Schrödinger answered. "The obvious inability of present-day physics and chemistry to account for such events," he wrote, "is no reason at all for doubting that they can be accounted for by those sciences."
It's a sentiment that has lured generations of physical scientists to biology.
For the past half-century, researchers have applied the rigorous tools of physics to help answer Schrödinger's question and unravel the fundamental mechanisms of life, but some of the most exciting challenges remain.
What are we doing in Biological Physics at Illinois?
The Experimental Biological Physics Research faculty's study includes, but is not limited to single-molecule methods, single-molecule fluorescence microscopy and spectroscopy, nucleic acid and protein translocases, DNA protein interactions, molecular biology, structure and dynamics of biological macromolecules.
The Theoretical and Computational Biological Physics Research faculty's study includes such ideas as biomolecular modeling of molecular motors, multiscale modeling of pattern formation, photosynthesis, cellular mechanics, multiscale modeling of cells and bionanotechnology.