Jaya G Yodh
Primary Research Area
- Biological Physics
For more information
- B.A. Biology, Concentration Biochemistry Cornell University 1987
- Ph.D. Biochemistry, Johns Hopkins University Bloomberg School of Public Health 1993
Professor Yodh is currently a Teaching Associate Professor in the Department of Biomedical and Translational Sciences at Carle Illinois College of Medicine (Carle Illinois). Her professional experience encompasses medical education in traditional and integrated curricular settings as well as interdisciplinary teaching, research, and administration bridging biological and quantitative sciences. Since joining Carle Illinois as an Inaugural Faculty in 2017, Dr. Yodh has held multiple educational roles as a Medical Education Problem-Based Learning (PBL) Facilitator, Biochemistry Thread Director and Instructor, and co-Director of the USMLE Step 1 Review course, Phase 1 Synthesis and Summary. Her current medical educational and research interests focus on integration of the basic sciences within systems-based curricula and engineering sciences, Step 1 Board Exam preparation, and innovations in PBL. She was a featured panelist in the 2021 International Association of Medical Science Educators Fall Webcast Audio Seminar Series where she discussed her recent publication, ‘How Covid-19 transformed online PBL at Carle Illinois College of Medicine (Coiado et. al., 2020). Further recognition for her educational research includes awards for Best Faculty Oral Presentation - Innovations in Medical Education at the 2021 American Association of Medical Colleges Virtual General Group on Educational Affairs Conference and the 2019 Scholar Award from the Association of Biochemistry Educators (ABE). She is currently leading a Clinical-Biochemistry Thread Mapping initiative with the ABE Educational Resource Development Committee.
Prior to joining Carle Illinois, Professor Yodh held positions on the Biochemistry Faculty at Midwestern University, Arizona College of Osteopathic Medicine in Glendale, Arizona from 1997-2006 where she taught students in the Doctor of Osteopathic Medicine, Physician Assistant, and Biomedical Sciences programs. She joined the UIUC faculty in 2006 holding positions as Research Faculty in the School of MCB (2006-2008) / Department of Physics (2008-present (0% since 2017)) and as Director of Education and Outreach for the NSF Physics Frontiers Center for the Physics of Living Cells (CPLC, 2008-2017). At Illinois, she taught Introductory Biochemistry and Experimental Biophysics Lab courses, and with the CPLC she directed advanced interdisciplinary research-based courses in biological physics including the globally recognized Physics of Living Cells Summer School, training 263 early career researchers from 110 institutions worldwide at the Urbana campus from 2009-2017. Over the course of her career, Professor Yodh has published several studies investigating DNA repair enzymology and chromatin structural dynamics using ensemble biochemical and single-molecule biophysical approaches including a seminal paper in Cell (Ngo, et. al., 2015) revealing a novel mechanism of gene regulation via sequence-dependent DNA physics. Professor Yodh received her B.A. from Cornell University in 1987 and Ph.D. from Johns Hopkins University in 1993. Her postdoctoral training, funded by an American Cancer Society Fellowship (1993-1997) was completed at Massachusetts General Hospital and Arizona State University.
- Teaching Associate Professor, Medical Education Facilitator, Department of Biomedical and Translational Sciences, Carle Illinois College of Medicine, 2019-present
- Research Associate Professor, Department of Physics (0%) 2019-present
- Director of Education and Outreach, National Science Foundation Physics Frontiers Center for the Physics of Living Cells (CPLC), Department of Physics, University of Illinois at Urbana-Champaign Urbana, IL. 2008-2017
Areas of Expertise in Teaching
- Problem-Based Learning (PBL) and Team-Based Learning (TBL) in medical education
- Teaching general and clinical biochemistry, molecular and cellular biology to undergraduate, graduate, and health professional students.
- Interdisciplinary research-based curriculum in biological physics for early career researchers and undergraduates in physics, biophysics, engineering, life sciences, chemistry disciplines.
- BSE 645 Phase 1 Synthesis and Summary SP 2020, 2021, 2022
- BSE 638 Endocrinology, Genitourinary, and Women's Health SU/FA 2020, 2021
- BSE 612 Foundations: Molecules to Populations SU 2020, 2021
- BSE 643 Immunology & Infection FA 2020
- BSE 642 Hematology & Oncology FA 2020
- BSE 641 Obstetrics FA 2019
- BSE 640 Women's Health FA 2019
- BSE 639 Genitourinary SU 2019
- BSE 638 Endocrinology SU 2019
- BSE 636 Digestion, Nutrition, and Metabolism SP 2020
- BSE 637 Nutrition and Metabolism SP 2019
- BSE 636 Digestion SP 2019
- BSE 635 Musculoskeletal SP 2019, 2020, 2021, 2022
- BSE 634 Clinical Neuroscience SP 2019, 2020, 2021
- BSE 633 Renal FA 2018, 2019, 2020
- BSE 632 Respiratory FA 2018, 2019, 2020
- BSE 631 Cardiovascular FA 2018, 2019, 2020
- BSE 613 Population Health SU 2018
- BSE 612 Foundational Elements SU 2021
- PHY 598/498 Biophysics Lab SP 2017
- MCB 450 Introductory Biochemistry SU 2008
Other Instructional Activities
- Co-Lead, CIMED Lifespan Health Thread, 2022-present
- Lead Course director, Foundations: Molecules to Populations, 2021-present
- CIMED Co-Course Director, Phase 1 Synthesis and Summary - USMLE Step 1 Review Course, 2017-present
- CIMED Biochemistry Core Discipline Lead, CIMED, 2017-present
- Interim Basic Science Course Co-Director, Endocrinology, CIMED, 2016
- 2017-2019 Facilitator Point Person for Carle Illinois College of Medicine Courses: Foundational Elements, Renal, Nutrition and Metabolism Endocrinology, Hematology-Oncology
- Curricular Innovations in Medical Education: Integration of Foundational Sciences with Clinical Sciences and Engineering; Problem-Based Learning (PBL)-based research; USMLE Step 1 Review Methods, Nutritional Health Sciences, Biophysics and Medicine
- Application of single-molecule biophysical tools to investigate mechanism and regulation of genome maintenance and gene expression by DNA structural dynamics. Biological systems studied include human Bloom Syndrome DNA repair helicase, G-quadruplex structures, and chromatin structure & dynamics.
Chapters in Books
Selected Articles in Journals
- Coiado OC, Yodh J, Galvez R, Ahmad K. “How COVID-19 Transformed Problem-Based Learning at Carle Illinois College of Medicine.” Medical Science Educator, 1-2. 24 Aug. 2020.
- Budhathoki, J., Maleki, P., Roy, W.A., Janscak, P., Yodh, J. G.*, Balci, H.* (2016) A Comparative Study of G-quadruplex Unfolding and DNA Reeling Activities of Human RECQ5 Helicase. Biophysical Journal 110 (12):2585–2596.
- Budhathoki, J.B., Stafford, E.J., Yodh, J.G.,* and Balci, H.,* (2015) ATP-dependent G-quadruplex unfolding by Bloom helicase exhibits low processivity. Nucleic Acids Research doi: 10.1093/nar/gkv531.
- Thuy T.M. Ngo, T.T.M, Zhang,Q., Zhou,R., Yodh,J.*, and Ha, T.* (2015) Asymmetric Unwrapping of Nucleosomes under Tension Directed by DNA Local Flexibility. Cell 160 (6):1135-1144
- Budhathoki,J.B., Ray,S., Urban,V., Janscak, P.,Yodh,J.G.*, and Balci, H.* (2014) RecQ-core of BLM unfolds telomeric G-quadruplex in the absence of ATP. Nucleic Acids Research 42 (18):11528-11545.
- Yodh J.G., Schlierf, M., Ha, T. (2010) In sight into helicase mechanism and function revealed through single-molecule approaches. Quarterly Review of Biophysics 43(2):185-217
- Kelbauskas L, Yodh J, Woodbury N, Lohr D. (2009), Intrinsic promoter nucleosome stability/dynamics variations support a novel targeting mechanism. Biochemistry 48(20):4217-9
- Yodh, J.G., B.C. Stevens, K. Radhakrishnan, P. Janscak and T. Ha, (2009) BLM helicase measures DNA unwound before switching strands and hRPA promotes unwinding reinitiation. The EMBO Journal 28: 405-416.
- Lohr, D., Bash, R., Wang, H. Yodh, J., and S. Lindsay (2007). Using atomic force microscopy to study chromatin structure and nucleosome remodeling. Methods 41(3): 333-341.
- Solis, F. J., Bash, R.,Wang, H., Yodh, J., Lindsay, S. A., and Lohr, D. (2007) Properties of nucleosomes in acetylated mouse mammary tumor virus versus 5S Arrays. Biochemistry 46(19), 5623-5634.
- Kelbauskas, L., Chan, N., Bash, R., Yodh, J. Woodbury, N., and D. Lohr (2007). Sequence-dependent nucleosome structure and stability variations detected by Forster Resonance Energy Transfer. Biochemistry 46(8): 2239-48.
- R. Bash, H. Wang, C. Anderson, J. Yodh, G. Hager, S.M. Lindsay, and D. Lohr (2006), "AFM imaging of proteins movements: Histone H2A-H2B release during nucleosome remodeling." FEBS Letters 580: 4757-4761.
- Lovullo, D., Daniel, D., Yodh, J., Lohr, D., and Woodbury, N.W. (2005) A fluorescence resonance energy transfer-based probe to monitor nucleosome structure.” Analytical Biochemistry 341, 165-172.
- H. Wang, R. Bash, J. G. Yodh, G. Hager, S. M. Lindsay, and D. Lohr (2004). Using Atomic Force Microscopy to Study Nucleosome Remodeling on Individual Nucleosomal Arrays in Situ. Biophysical J. 87, 1964-1971.
- Solis, F. J., Bash, R., Yodh, J., Lindsay, S. M., and Lohr, D. (2004) A Statistical Thermodynamic Model Applied to Experimental AFM Population and Location Data Is Able to Quantify DNA-Histone Binding Strength and Internucleosomal Interaction Differences between Acetylated and Unacetylated Nucleosomal Arrays. Biophysical J. 87, 3372-3387.
- Bash, R., Wang, H., Yodh, J., Hager, G., Lindsay, S. M., and Lohr, D. (2003) Nucleosomal arrays can be salt-reconstituted on a single-copy MMTV promoter DNA template: Their properties differ in several ways from those of comparable 5S concatameric arrays. Biochemistry 42(16), 4681 - 4690.
- Wang, H., Bash, R., Yodh, J. G., Hager, G. L., Lohr, D., and Lindsay, S. M. (2002) Glutaraldehyde modified mica: A new surface for atomic force microscopy of chromatin. Biophysical J. 83, 3619-3625.
- Yodh, J. G., Woodbury, N., Shlyatenko, L., Lyubchenko, Y., and Lohr, D. (2002) Mapping nucleosome locations on the 208-12 by AFM provides clear evidence for cooperativity in array occupation. Biochemistry 41(11), 3565-3574.
- Bash, R., Yodh, J. G., Lyubchenko, Y., Woodbury, N., and Lohr, D. (2001) Population analysis of subsaturated 172-12 nucleosomal arrays by atomic force microscopy detects nonrandom behavior that is favored by histone acetylation and short repeat length. J. Biol. Chem. 276(51), 48362-48370
- Yodh, J.G., Lyubchenko, Y., Shlyatenko, L, Woodbury, N., and Lohr, D (1999) Evidence for non-random behavior in 208-12 subsaturated nucleosomal array populations analyzed by AFM. Biochemistry 38(48),15764-15733.
- Yodh, J. G. and Bryant, F. R. (1993) Kinetics of ATP hydrolysis during the DNA helicase II - promoted unwinding of duplex DNA. Biochemistry 32, 7765-7771.
- Winter, W. P., Seale, W., and Yodh, J. (1984) Interaction of hemoglobin S with anionic polysaccharides. Amer. J. Pediatric Hematology Oncology. 6 (1), 77-82.
- Winter, W. P. and Yodh, J. (1983) Interaction of human hemoglobin and its variants with agar. Science 221, 175-178.
- IL Alumni Magazine Spring 2020 In-Class Profile - Medical Education Facilitator
- Discover Magazine Galleries 2018 Microscopy : Cambion,' by Jaya G. Yodh, IGB Core Facilities
- 2015 IGB Research - Scientists-find-DNA-packaged-yoyo
Conferences Organized or Chaired
- Yodh, J. (Lead), Spicer, D., Zaidi, A., Abali, E., Joshi, V., “Creating a Clinical-Biochemistry Thread Map Across Pre-Clerkship and Clerkship Curriculum.” Workshop B-02 Leader, May 3, 2021 at The Association of Biochemistry Educators/Association of Professors of Human and Medical Genetics (ABE/APHMG) Joint Virtual Meeting, May 3-7, 2021.
- Spicer, D (Lead)., Baleja, J., Binstock, J., Joshi, V., Zaidi, A., Abali, E., Sharkady, S., Manzerra, P., Yodh, J., “Finding the Clinical Relevance in the ABE Learning Objectives.” Workshop B-03 Facilitator, May 4, 2021 at The Association of Biochemistry Educators/Association of Professors of Human and Medical Genetics (ABE/APHMG) Joint Virtual Meeting, May 3-7, 2021.
- Association of Biochemistry Educators (ABE), 2019- present; ABE Educational Resource Development Committee (Lead Biochemistry Thread Mapping Project), 2020-present
- American Association for the Advancement of Science (AAAS)
- American Association of Medical Colleges (AAMC), Central Group on Educational Affairs (CGEA)
- American Society for Biochemistry and Molecular Biology (ASBMB)
- International. Association of Medical Science Educators (IAMSE)
- Biophysical Society (BPS)
Service on Department Committees
- Biomedical and Translational Sciences (BTMS) Department, APT Promotion Policy Subcommittee. 2021
- UIUC Physics Department Diversity Committee. 2015-2017
Service on College Committees
- Carle Illinois College of Medicine (CI MED) Curriculum Evaluation Committee. Aug. 2021-present
- CI MED Curriculum Oversight Committee (COC). 2018-2021. Vice-Chair (2018-19); Chair (2019-2020); COC Pre-clerkship Curriculum Sub-Committee Feb.2018-Apr 2019
- CI MED Social Determinants of Health Task Force. 2020-present
- CI MED Student Progress and Promotions Committee. July 2021-present
- CI MED Health Innovation Research Day Awards Subcommittee, Co-Chair, 2020-2021
- University of Illinois Colelge of Medicine (UICOM) Racial Reform and Social Justice Task Force and Curriculum Subcommittee. 2020-2021
- CI MED Director of Program Evaluation and Student Assessment Search Committee. April-June 2020
- CI MED Academic Promotion and Tenure (APT) Committee. 2018-2021. Clinical Faculty Recalibration Subcommittee 2019-2020.
- CI MED Medical Education Department of Biomedical and Translational Sciences Head Search Committee. June – Dec 2019
- CI MED Medical Education Facilitator Search Committee. Jan-May 2019
- CI MED Academic Skills Specialist Search Committee. Jan.-June 2018
Service on Campus Committees
- 2021-present UIUC Faculty Senate Representative for Carle Illinois College of Medicine
- 2015-2017 Member, UIUC Gender Equity Council
Other Outside Service
- From 2008 to 2017, Professor Yodh served as Director of Education and Outreach for The Center for the Physics of Living Cells (CPLC), an NSF-funded Physics Frontiers Center at the University of Illinois. In this position, she directed upper level outreach activities including the Physics of Living Cells (CPLC) Summer School, Junior Nanotech Network (JNN) International exchange program and was co-PI and lead administrator for the Illinois node of the NSF multi-institutional International Physics of Living Systems Collaborative Student Research Network (iPOLS-SRN). These efforts helped to establish Illinois as a global hub for training of next-generation scientists studying the physics of biological systems. Dr. Yodh also supervised Center K-12 and Diversity outreach efforts and served as the Center’s grant administrator and manager.
- Association of Biochemistry Educators (ABE) Scholar Award, 2019
- American Association of Medical Colleges (AAMC) Central Group on Educational Affairs (CGEA) Best Faculty Oral Presentation - Innovations in Medical Education, 2021
- International Association of Medical Educators Early Career Award in Teaching and Innovation, 2022
Recent Courses Taught
- BSE 612 - Foundational Elements
- BSE 633 - Renal